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Monday, April 19, 2021

$0.0217 Price to Beat: Enzolytics Inc (OTCMKTS: ENZC); BioClonetics Merger

Enzolytics Inc (OTCMKTS: ENZC) is running up the charts recently going into full beast mode as it once again moved well into penny land. Over the past few months ENZC has seen a historic rise off its triple zero lows to recent highs of $0.0217s which is the price to beat for confirmation of the next leg up. The rise on ENZC comes as the Company merges with BioClonetics Immunotherapeutics, Inc. a biotech in the final stage of development of a parent monoclonal antibody that is being tested at the California National Primate Research Center, UCDavis for the development of a COVID-19 antibody. BioClonetics Clone 3 recombinant mAbs will be combined with the Enzolytics’ flagship compound ITV-1 which is a suspension of Inactivated Pepsin Fragment (IPF), which studies have shown is effective in the treatment of HIV. Thereafter  PBMC based in-vitro neutralization studies will be conducted with the Enzolytics ITV-1 peptide in combination with the BioClonetics Clone 3 antibodies. Based on the results, the best combination with be tested in primate studies at the California National Primate Research Center University of California, Davis, California.

ENSC management is working hard behind the scenes compiling the information to bring current its OTC filings. The company has begun the process of identifying a clinical research organization for the preparation of pre-IND protocols for submission to the FDA and is also in the final interviews with several pharmaceutical manufacturing companies to produce the validation order. Enzolytics has also procured a commitment for funding of $500,000.00 to be used for implementation of the planned combined operations and the initial steps of the merged business strategy of creating successful therapeutics against infectious diseases thereby increasing the value of the Company’s technology and the value of the Company through the combination the Enzolytics ITV-1 peptide in conjunction with BioClonetics’ anti-HIV monoclonal antibodies.

Enzolytics Inc (OTCMKTS: ENZC) is a drug development company committed to the commercialization of its proprietary proteins for the treatment of debilitating infectious diseases. Enzolytics is committed to creating drugs for the better health of mankind. Enzolytics, Inc. is also a 49% shareholder in IMMB BG its Bulgarian subsidiary. Enzolytics, Inc.’s flagship compound ITV-1 is a suspension of Inactivated Pepsin Fragment (IPF), which studies have shown is effective in the treatment of HIV. IPF is the active drug substance of ITV-1 and is a purified extract of porcine pepsin. ITV-1 has been shown to modulate the immune system. IPF is a platform technology that can be used to facilitate a broad range of applications. It is free from major neurological, gastrointestinal and hematological side effects seen in the anti-retrovirals in use today. IPF has not shown to be subject to viral resistance and is cost effective.

BioClonetics Immunotherapeutics, Inc. is a Dallas Texas biotech company with proprietary technology for producing fully human monoclonal antibodies (mAbs) against infectious diseases including HIV, rabies, influenza A, influenza B, tetanus, and diphtheria. Its proprietary methodology for producing fully human monoclonal antibodies may be used to produce therapeutic fully human monoclonal antibodies for treating many infectious diseases including the Coronavirus.

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ENZC

Several weeks ago the Company executed a binding LOI to merge with BioClonetics Immunotherapeutics, Inc replacing the earlier non-binding letter signed on September 12, 2020. BioClonetics is in the final stage of development of a parent monoclonal antibody (“mAbs”) (designated as Clone 3), which is non-toxic and has shown in initial in vitro testing to be effective against more than 95% of all strains and viral subtypes of HIV-1 against which it has been tested. Final testing of BioClonetics’ anti-HIV recombinant mAbs in PBMC neutralization assays are being conducted to be followed by animal trials at the California National Primate Research Center, UCDavis (Davis, CA).

The proposed merger anticipated in the LOI will result in Charles Cotropia being appointed as CEO of the merged entity and Harry Zhabilov and Joseph Cotropia, MD, being appointed as co-CSO. Gaurav Chandra, MD, will serve as COO of the merged entity. Charles Cotropia was appointed to the ENZC Board of Directors on October 1, 2020 and will enter into an employment contract with the Company at or prior to the closing of the contemplated transaction.

In an update management stated: Additionally, we will use AI (artificial intelligence) to analyze the 16,000 known sequences of different SARS-Cov-2 viruses that have now been catalogued in the Los Alamos National Laboratory, with multiple different strains identified. By using computer analysis, several conserved (expectedly immutable and neutralizable) sites on the virus can be identified and additional monoclonal antibodies produced against these- to be used in a monoclonal antibody “cocktail”. We all have now heard of the “monoclonal antibody cocktail” administered to President Donald Trump. This is exactly what we propose – note that there are numerous different anti-SARS-Cov-2 monoclonal antibodies that can exist – some disease neutralizing and some perhaps of no benefit and some perhaps disease enhancing. Recall that the NIH and big pharma tried for 35 years to produce neutralizing antibodies against HIV and failed – notable evidence being the millions spent of the monoclonal antibodies VRC01 and VRC02 – produced by Vaccine Research Center in conjunction the NIH – both failed in trials because of “virus escape” – meaning they “targeted a site on the virus that mutates and thus the virus escapes the therapeutic effect”. The key is to produce monoclonal antibodies that target a conserved, immutable site on the virus such that the virus cannot mutate around the antibody therapeutic.

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Currently going parabolic on the OTCQB ENZC has skyrocketed out of sub penny land and its triple zero lows attracting legions of shareholders and emerging as a volume leader in small caps. The rise on ENZC comes as the Company merges with BioClonetics Immunotherapeutics, Inc. a biotech in the final stage of development of a parent monoclonal antibody that is being tested at the California National Primate Research Center, UCDavis for the development of a COVID-19 antibody. BioClonetics Clone 3 recombinant mAbs will be combined with the Enzolytics’ flagship compound ITV-1 which is a suspension of Inactivated Pepsin Fragment (IPF), which studies have shown is effective in the treatment of HIV. IPF is the active drug substance of ITV-1 and is a purified extract of porcine pepsin. ITV-1 has been shown to modulate the immune system. IPF is a platform technology that can be used to facilitate a broad range of applications. It is free from major neurological, gastrointestinal and hematological side effects seen in the anti-retrovirals in use today. IPF has been shown to not be subject to viral resistance and is cost effective. Thereafter, PBMC based in-vitro neutralization studies will be conducted with the Enzolytics ITV-1 peptide in combination with the BioClonetics Clone 3 antibodies. Based on the results, the best combination with be tested in primate studies at the California National Primate Research Center University of California, Davis, California. ENSC management is working hard behind the scenes compiling the information to bring current its OTC filings. Enzolytics has also procured a commitment for funding of $500,000.00 to be used for implementation of the planned combined operations and the initial steps of the merged business strategy of creating successful therapeutics against infectious diseases thereby increasing the value of the Company’s technology and the value of the Company through the combination the Enzolytics ITV-1 peptide in conjunction with BioClonetics’ anti-HIV monoclonal antibodies.We will be updating on ENZC when more details emerge so make sure you are subscribed to Microcapdaily so you know what’s going on with ENZC.

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Disclosure: we hold no position in ENZC either long or short and we have not been compensated for this article.

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