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Monday, October 25, 2021

MCET (MultiCell Technologies) Surging Higher on Fa N2-4 immortalized Human Hepatocytes Cell Lines Patent

MCET (MultiCell Technologies) has been heating up and running northbound in recent weeks running out of the triple zeroes and trading more volume with a recent high of $0.0016 per share. MCET has been around for years and once owned a valuable patent portfolio however many of these patents were lost due to the Company not filing the mandatory maintenance fee at 4, 8 and at twelve years after the U. S. Patent office granted them patents.  

However, there is a growing number of shareholders led by MCET dreamer who believe the Company still owns a number of valuable patents including the Fa2N-4 patent, a patent they believe is being infringed upon by a number of Companies. MCET management is aging and the CEO is in his 80s and Investors in the Company are looking for someone to take charge. Currently the stock is pink no information on otcmarkets.com which is a shame, the Company has a lot of shareholders, thousands of them and still does own a number of patents we know of for sure. In this market it would be so easy for any controlling shareholder to step in, do some basic housekeeping and bring value to shareholders. 

MCET (MultiCell Technologies) is a biopharmaceutical company developing therapeutic candidates based on modulation of the immune system plus new antiviral treatments to address influenza and other infectious diseases. 

It is not exactly certain who is currently in charge of the Company; it could be the Company’s old CEO Jerry Newmin who is now close to 80 years old or his wife Barbara or the Company’s director, Ed Sigmond; a Partner at Sigmond & Johnson, Inc. Mr. Sigmond was also President at Kestrel Holdings, Inc., Chairman, CEO & Head-Investor Relations at The Great American Food Chain, Inc., Managing Partner & Owner at The Elbow Room, and a Director & Partner at Na Zdravi Ventures. He is/was on the Board of Directors at MultiCell Technologies, Inc.   

MultiCell intellectual property was focused in the area of drug discovery and stem cells and the patented Sybiol(TM) synthetic bio-liver therapeutic liver assist device. MultiCell holds two patents on novel strategies for isolation of adult human liver cells, and cell clusters or doublets, invented by Dr. Ronald A. Faris, Senior Vice President and Chief Scientific Officer of MutliCell and Director of Research with Rhode Island Hospital. Obtaining stem cells from adult tissues avoids the ethical issues and the contamination issues associated with embryonic or fetal stem cells. Liver stem cells may play a key role in transplantation for tissue regeneration and therapeutic use including the clinical management of metabolic liver disorders and heart disease as well as potential diagnostic applications. The use of liver stem cells to treat diseases, such as Hepatitis C, may greatly enhance quality of life and avoid costly whole organ liver transplantation. MultiCell believes its patented stem cell techniques are unique within the cell therapy market. 

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MCET has been around for years and once owned a valuable patent portfolio however many of these patents were lost due to the Company not filing the mandatory maintenance fee at 4, 8 and at twelve years after the U. S. Patent office granted them patents.  However, there is a growing number of shareholders led by MCET dreamer who believe the Company still owns a number of valuable patents including the Fa2N-4 patent, a patent they believe is being infringed upon by a number of Companies. MCET management is aging and the CEO is in his 80s and Investors in the Company are looking for someone to take charge. Currently the stock is pink no information on otcmarkets.com which is a shame, the Company has a lot of shareholders, thousands of them and still does own a number of patents we know of for sure. In this market it would be so easy for any controlling shareholder to step in, do some basic housekeeping and bring value to shareholders.  

Back in 2009 MCET was granted U.S. patent 7,566,567 by the United States of America Patent and Trademark Office covering its Fa2N-4 and Ea1C-35 immortalized human hepatocyte cell lines. The Fa2N-4 and Ea1C-35 immortalized human hepatocyte cell lines were derived from normal human liver cells, and are nontumorigenic, stable in culture, and produce therapeutic plasma proteins in cell culture. The Fa2N-4 cell line has also been engineered to function as a proxy for normal human liver cells for use in performing drug toxicity assays. 

MultiCell licensed Corning, Inc. to sell the Fa2N-4 cell line and media within the drug discovery and life science research markets for drug toxicity (Tox) applications as well as for drug adsorption, distribution, metabolism and excretion (ADME) studies. MultiCell retained worldwide exclusive ownership of the Fa2N-4 and Ea1C-35 cell lines for all applications other than ADME/Tox, including drug target identification and using the cell lines for the production of therapeutic plasma proteins.  

The role of liver stem cells in the carcinogenic process has recently led to a new hypothesis that hepatocellular carcinoma in humans arises by maturation arrest of liver stem cells. Jerry Newmin, Chairman & CEO of MultiCell Technologies commented at the time of this release in 2009: “MultiCell intends to use its human liver cell and liver stem cell assets to identify therapeutic targets and new drug candidates specifically targeting the treatment of primary liver cancer and intrahepatic bile duct cancer. We believe our engineered human liver cell lines will play an important role as proxies for normal human liver cells in our effort to identify drug targets.”  

Microcapdialy has written about MCET before. Back in 2015 we wrote of MCET: “MultiCell Technologies, Inc. (OTCMKTS:MCET) made a big move up today off its $0.0002 lows on massive volume. The move is a huge welcome to shareholders who have endured months of nothing since the run this one made in March 2014. The big move today came after MCET announced a research & development and product license agreement with Oxis Biotech to create three novel antibody-drug conjugates (ADCs) containing OXIS’ lead drug candidates using MCIT’s proprietary ADC platform technology. MultiCell Technologies, Inc. (OTCMKTS:MCET) is a clinical-stage biopharmaceutical company developing novel therapeutics and discovery tools for the treatment of neurological disorders, hepatic disease and cancer. MCET majority owned subsidiary is MultiCell Immunotherapeutics, a biotechnology company developing novel therapeutics and drug delivery platform technologies to treat a variety of human diseases. MCIT’s next-generation antibody drug conjugates provide for the simultaneous targeted delivery of multiple drugs from a single antibody. This unique, targeted co-delivery capability enables the localization of both drugs within a target cell where they exert their biological effect and helps to minimize adverse off-target effects.” MCET drug candidate, MCT-125, is an oral small molecule drug combination which targets the noradrenaline-adrenaline neurotransmitter pathway for the treatment of primary multiple sclerosis-related fatigue (PMSF). Primary multiple sclerosis-related fatigue (PMSF) affects over 70% of all persons with multiple sclerosis (MS). MCT-125 has demonstrated efficacy in a 138 patient Phase 2a clinical trial for the treatment of PMSF.

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MCET has been around for years and once owned a valuable patent portfolio however many of these patents were lost due to the Company not filing the mandatory maintenance fee at 4, 8 and at twelve years after the U. S. Patent office granted them patents. However, there is a growing number of shareholders led by MCET dreamer who believe the Company still owns a number of valuable patents including the Fa2N-4 patent, a patent they believe is being infringed upon by a number of Companies. MCET management is aging and the CEO is in his 80s and Investors in the Company are looking for someone to take charge. Currently the stock is pink no information on otcmarkets.com which is a shame, the Company has a lot of shareholders, thousands of them and still does own a number of patents we know of for sure. In this market it would be so easy for any controlling shareholder to step in, do some basic housekeeping and bring value to shareholders. We here at MicroCapDaily wish nothing but the best for MCET shareholders. We hope the stock goes way up. We will be updating on MCET when more details emerge so make sure you are subscribed to Microcapdaily so you know what’s going on with MCET.

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Disclosure: we hold no position in MCET either long or short and we have not been compensated for this article.

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