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Tuesday, April 20, 2021

Is Generex Biotechnology Corporation (OTCMKTS:GNBT) Warming Up for a Run?

Generex Biotechnology Corporation (OTCMKTS:GNBT) has seen a massive explosion of trading volume after the Company reported on October 7; ‘Generex Clarifies Utility of Antigen Express Technology for Potential Ebola Vaccine.

Simply the word Ebola in the release was enough to double the stock in minutes and make the otherwise fairly quiet GNBT one of the top most traded stocks on the entire OTCBB market.

Generex Biotechnology Corporation (OTCMKTS:GNBT) is engaged in the research, development, and commercialization of drug delivery systems and technologies. Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Company’s proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Company’s proprietary RapidMist™ device.

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Antigen Express, Inc. is a wholly owned subsidiary of Generex. The core platform technologies of Antigen Express comprise immunotherapeutic vaccines for the treatment of malignant, infectious, allergic, and autoimmune diseases. Antigen Express has pioneered the use of specific CD4+ T-helper stimulation technologies in immunotherapy. One focuses on modification of peptides with Ii-Key to increase potency, while a second relies on inhibition of expression of the Ii protein. Antigen Express scientists, and others, have shown clearly that suppression of expression of the Ii protein in cancer cells allows for potent stimulation of T-helper cells and prevents the further growth of cancer cells.

On October 7 GNBT responded to a recent article posted to the Seeking Alpha website regarding the need for an Ebola vaccine and the importance of providing funding for small companies with technologies applicable to such an endeavor. Generex is the parent company of Antigen Express, Inc. which focuses on the development of synthetic peptide vaccines for significant unmet medical needs.

Antigen Express has previously published its work on the development of a vaccine for potentially pandemic viruses such as the H5N1 (avian flu) and H1N1 (swine flu) influenza strains. The advantage of the technology is that it entails entirely synthetic production methods, which are rapid, cost effective, and flexible. The vaccine is produced using a small fragment derived from a target protein modified to ensure activation of CD4+ T helper cells. This cell type is critical in the generation of an effective immune response to a novel agent.

Antigen Express remains committed to its belief that a synthetic vaccine technology is a crucial component of a government’s preparedness arsenal for outbreaks of agents with high pathogenicity such as Ebola or the emergence of other potentially pandemic agents. Toward that goal, the Company is exploring opportunities for application of Antigen Express technology in the development of an effective Ebola vaccine.

There are currently a number of vaccines in development for Ebola, though none have yet been approved. Some of these require repeated administration to obtain some level of protection in animal models, in contrast to the influenza virus vaccines. Early efforts to generate a protective antibody response against Ebola clearly showed the importance of CD4+ T cells. The need for continued or repeated immunization is a good indication of the need for a stronger CD4+ T cell response, as specific activation of this cell type is associated both with immunological memory as well as a robust early response to immunization.

Conclusion: GNBT seems to have lost investors confidence a long time ago and currently hovers over the penny support. This one has had several short run ups topping out a nickel over the past 2 years with the trading range being $0.01 to $0.05.

Currently trading at a $16.3 million market valuation the Company has a fairly strong cash position of $4 million in the treasury however to date there have been no revenues. A significant sustained run on this one would start with the eclipse of the $0.05 and go from there, until that happens GNBT is stuck where it is…

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Disclosure: we hold no position in GNBT either long or short and we have not been compensated for this article.

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