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Major Resurgence on BioClonetics; Enzolytics, Inc. (ENZC) Engineered Monoclonal Antibodies & Potent, Non-Toxic Peptides

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Enzolytics, Inc. (ENZC) is in full beast mode rocketing up the charts in recent days since a brief dip below the $0.40 mark. The stock has been under heavy accumulation recently and volume has picked up substantially since early September when Microcapdaily first covered ENZC when it was just under a penny as a new era of penny stock speculators fueled by robinhood and its 100 million new trading accounts take on the bulletin boards. These are different times than just a few short years ago; now penny stocks such as TSNP can achieve a $6 billion plus market valuation and trade $375 million in dollar volume in a day on the bulletin boards. And TSNP has no stronger fundamentals than ENZC does.   

Enzolytics and its new subsidiary BioClonetics own licensing rights of the Irreversible Pepsin Fraction peptide molecule for the treatment of HIV/AIDS a market expected to be worth $30 billion plus by 2025. The Company also produces targeted (nontoxic) monoclonal antibodies and is now advancing two separate but complementary therapy platforms for treating infectious diseases, targeting HIV and the CoronaVirus. Enzolytics has attracted a major league level management team behind it and has expanded its lab capabilities on the Texas A&M University campus at the Institute for Pre-clinical Studies, where it is producing both addition monoclonal antibodies against HIV and the against covid-19. Last week ENCZ announced the results of an in vitro study of the Company’s ITV-1/IPF peptide treatment that demonstrated the broad efficacy with low toxicity. The Company’s ITV-1 peptide was tested against human corona virus 229E Strain (HCoV-229E) and exhibited comparable efficacy but with a 20-fold lower toxicity than the widely used anti-influenza medicine Tamiflu®. CSO Harry Zhabilov states, “The company has long believed in the efficacy of its product and the results of this study are further evidence of ITV-1 efficacy with low toxicity.”

Enzolytics, Inc. (ENZC) is a drug development company committed to the commercialization of its proprietary proteins for the treatment of debilitating infectious diseases. Enzolytics‘ flagship compound ITV-1 (Immune Therapeutic Vaccine-1) is a suspension of Inactivated Pepsin Fraction (IPF), which studies have shown is effective in the treatment of HIV/AIDS. IPF is the active drug substance of ITV-1 and is a purified extract of porcine pepsin. ITV-1 has been shown to modulate the immune system.

ENZC recently merged with BioClonetics Immunotherapeutics; a Dallas and College Station, Texas biotech company with proprietary technology for producing fully human monoclonal antibodies (mAbs) against infectious diseases including HIV, rabies, influenza A, influenza B, tetanus, and diphtheria. Its proprietary methodology for producing fully human monoclonal antibodies may be used to produce therapeutics treatments for many infectious diseases including the Coronavirus.

The newly combined Companies are led by CEO and majority shareholder Charles S. Cotropia, a well-known intellectual property attorney who has litigated over 200 patents in his career and served as lead counsel in several landmark patent disputes litigated in Federal Courts and the US Patent and Trademark Office. Mr. Cotropia founded BioCLonetics along with his brother Dr. Joseph Cotropia, MD, who pioneered BioCLonetics proprietary method for creating human cell lines that produce human antibodies directed against many infectious diseases. One cell (designated as CLONE 3) has been demonstrated in multiple tests and 5 Independent studies to neutralize the HIV virus in 98% of all known varieties world-wide. 

ENZC has been rapidly building up an intellectual property portfolio filing numerous patents last year. Most recently, last month, the Company reported it has received the official filing receipt from the U.S. Patent Office confirming the filing of its patent application for “Nuclear Proteins Isolated from Mammalian Spinal Cord Immune Factor – Pharmaceutical Composition for Treatment.”  

The Company’s Genetics and Molecular Biology data science team is now screening (using computer analysis/Artificial Intelligence [AI]) more than 275,000 CoronaVirus isolates now known, to also identify conserved sites which expectedly are immutable. From this information, anti-SARS-CoV-2 (CoronaVirus) monoclonal antibodies will be produced. The significance of producing monoclonal antibodies against conserved target sites on targeted viruses is made evident by the mutant strains of the CoronaVirus currently surfacing in the U.S, South Africa, Brazil, United Kingdom and around the world. The same virus mutation exists with HIV, as well as other well-known viruses. As a virus mutates, a therapeutic becomes ineffective when it neutralizes by attacking a site that changes. By targeting an immutable site, a therapeutic is not affected by the mutation. This is well understood by the necessity to produce a new flu vaccine with each flu season, namely because the flu virus mutates. Producing therapeutics that target a conserved site on viruses makes possible the production of a therapeutic that is not rendered ineffective by virus mutation, and therefore can be applied successfully both universally around the world and durably over time.  

Investor sentiment on ENZC is very high:

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ENZC is also applying Artificial Intelligence [AI] to scan the hundreds of thousands of isolates that exist in 14 other prevalent viruses, ranging from influenza to Rabies to Ebola. Using the Company’s proprietary technique for producing fully human monoclonal antibodies directed against these infectious diseases, the Company will produce multiple neutralizing monoclonal antibodies against these viruses. The significance of this approach is well recognized by experts in virology due to the ability of all viruses to mutate and render ineffective initially developed therapeutics.  

On February 16 ENZC announced the results of an in vitro study of the Company’s ITV-1/IPF peptide treatment that demonstrated the broad efficacy with low toxicity. The Company’s ITV-1 peptide was tested against human corona virus 229E Strain (HCoV-229E) and exhibited comparable efficacy but with a 20-fold lower toxicity than the widely used anti-influenza medicine Tamiflu®.

Currently, the ITV-1/IPF therapeutic is being scheduled for further clinical trials to establish the breath of efficacy of the therapeutic. The just completed study was conducted by Professor Petia Genova-Kalou, at the National Centre of Infectious and Parasitic Diseases in Sofia, Bulgaria. In the study, the antiviral capability of Enzolytics‘ ITV-1/IPF peptide inhibitor was measured in comparison to oseltamivir phosphate (Tamiflu®) in an in-vitro testing on cell cultures. The tests examined the effect of ITV-1/IPF on HCoV-229E (human corona virus 229E). The results show that while the tested therapeutics had comparable effectiveness, ITV-1/IPF had a 20-fold lower toxicity than the widely used anti-influenza medicine Tamiflu®. After the 96th hour of treatment, the ITV-1/IPF displayed this significantly lower toxicity. The experiment used from 0.001mg/ml to 1 mg/ml of ITV-1/IPF and Tamiflu® in concentration of range 0.005-2.5 mg/ml. Results showed that when both products were tested in the concentrations mentioned above, the efficacy of ITV-1/IPF against HCoV-229E was 65% and Tamiflu® was 75.5% against the same strain. While the measured effectiveness was comparable, Tamiflu® was found to be 20-fold more toxic than ITV-1/IPF.

CSO Harry Zhabilov states, “The company has long believed in the efficacy of its product and the results of this study are further evidence of ITV-1 efficacy with low toxicity.” 

https://twitter.com/mattyahmz/status/1363031009235595267

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ENZC is in full beast mode rocketing up the charts in recent days since a brief dip below the $0.40 mark. The stock has been under heavy accumulation recently and volume has picked up substantially since early September when Microcapdaily first covered ENZC when it was just under a penny as a new era of penny stock speculators fueled by robinhood and its 100 million new trading accounts take on the bulletin boards. These are different times than just a few short years ago; now penny stocks such as TSNP can achieve a $6 billion plus market valuation and trade $375 million in dollar volume in a day on the bulletin boards. And TSNP has no stronger fundamentals than ENZC does. Enzolytics and its new subsidiary BioClonetics own licensing rights of the Irreversible Pepsin Fraction peptide molecule for the treatment of HIV/AIDS a market expected to be worth $30 billion plus by 2025. The Company also produces targeted (nontoxic) monoclonal antibodies and is now advancing two separate but complementary therapy platforms for treating infectious diseases, targeting HIV and the CoronaVirus. Enzolytics has attracted a major league level management team behind it and has expanded its lab capabilities on the Texas A&M University campus at the Institute for Pre-clinical Studies, where it is producing both addition monoclonal antibodies against HIV and the against covid-19. Last week ENCZ announced the results of an in vitro study of the Company’s ITV-1/IPF peptide treatment that demonstrated the broad efficacy with low toxicity. The Company’s ITV-1 peptide was tested against human corona virus 229E Strain (HCoV-229E) and exhibited comparable efficacy but with a 20-fold lower toxicity than the widely used anti-influenza medicine Tamiflu®. CSO Harry Zhabilov states, “The company has long believed in the efficacy of its product and the results of this study are further evidence of ITV-1 efficacy with low toxicity. We will be updating on ENZC when more details emerge so make sure you are subscribed to Microcapdaily so you know what’s going on with ENZC.

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Disclosure: we hold no position in ENZC either long or short and we have not been compensated for this article.

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