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Sunday, October 17, 2021

Sunshine Biopharma, Inc. (OTCMKTS:SBFM) Major Move as its Anticancer Drug Candidate Adva-27a Gains Traction

Sunshine Biopharma, Inc. (OTCMKTS:SBFM) was up well over 100% on Tuesday after the Company announced it has elucidated the mechanism of action of Adva-27a, the Company’s flagship anticancer drug candidate. Adva-27a has been found to have two activities: (i) evasion of P-glycoprotein, and (ii) inhibition of Topoisomerase II. P-glycoprotein is the most often encountered transmembrane efflux protein responsible for multidrug resistance in over 50% of all cancer types. By escaping the efflux pump of P-glycoprotein, Adva-27a is able to accumulate inside cancer cells and destroy them by inhibiting Topoisomerase II, a DNA unwinding enzyme preferentially used by cancer cells to multiply. 

SBFM took off northbound up the charts earlier this year as the Company’s covid treatment began to gain traciton. In March the Company reported a $2 million investment from RB Capital Partners Inc to further the Company’s covid treatment. Sunshine Biopharma’s COVID-19 treatment is an inhibitor of PLpro, a protease present only in the SARS Coronaviruses (Betacoronaviruses) and is an important antiviral target as it is involved in shutting down the host innate immune system thereby causing significantly greater morbidity. 

Sunshine Biopharma, Inc. (OTCMKTS:SBFM) is hard at work developing its treatment for COVID-19. The Company is also engaged in the development Adva-27a, a unique anticancer compound. Tests conducted to date have demonstrated the effectiveness of Adva-27a at destroying Multidrug Resistant Cancer Cells, including Pancreatic Cancer cells, Small-Cell Lung Cancer cells, Breast Cancer cells, and Uterine Sarcoma cells. Clinical trials for Pancreatic Cancer indication are planned to be conducted at McGill University’s Jewish General Hospital in Montreal, Canada. Sunshine Biopharma is owner of all patents and intellectual property pertaining to Adva-27a. 

Microcapdaily first reported on SBFM on April 4, 2015 stated at the time: “SBFM traded for well over $1 in 2011 and was over $0.25 for most of 2012 as many investors put significant money into this stock because they believed in Dr. Steve N. Slilaty and his vision for Adva-27a. This vision never came to fruition however and SBFM collapsed as insiders cashed in their chips and let the stock drift into oblivion decimating the original shareholder’s investment in the Company. The result is a large group of investors who were wiped out by SBFM and are understandably very angry with Dr. Steve N. Slilaty who was recently seen driving about town in his new black BMW M6 convertible. As SBFM hit its lowest point just over a penny Bombaykid stepped in to save the day stating: ”that is not true, i work for lonza in india and sunshine pharma just bought a 10,000square feet facility, i will be working for it sunshine plant in india me very happy. Veri good news come out next week say doct karithe, veri powerful in india, doct karithe veri veri smart. Very very cheap, me buy cheap low, keep high india smart buiness peoples.” 

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On the covid front SBFM recently reported it has successfully completed a Maximum Tolerated Dose (MTD) study in mice. Sunshine Biopharma is pleased to report that the MTD results are favorable and fall within the optimum range for use in humans. Next, Sunshine Biopharma will use the test dose indicated by these results to conduct the efficacy studies in hACE2-transgenic mice. Sunshine Biopharma’s COVID-19 treatment is an inhibitor of PLpro, a protease present only in the SARS Coronaviruses (Betacoronaviruses) and is an important antiviral target as it is involved in shutting down the host innate immune system thereby causing significantly greater morbidity. Management stated they were delighted its compound passed this critical toxicology step with flying colors. 

On May 25 SBFM announced it has elucidated the mechanism of action of Adva-27a, the Company’s flagship anticancer drug candidate. Adva-27a has been found to have two activities: (i) evasion of P-glycoprotein, and (ii) inhibition of Topoisomerase II. P-glycoprotein is the most often encountered transmembrane efflux protein responsible for multidrug resistance in over 50% of all cancer types. By escaping the efflux pump of P-glycoprotein, Adva-27a is able to accumulate inside cancer cells and destroy them by inhibiting Topoisomerase II, a DNA unwinding enzyme preferentially used by cancer cells to multiply. 

Multidrug resistance is by far the biggest challenge in cancer therapy and P-glycoprotein is the major culprit. A plethora of anticancer drugs that are central to chemotherapeutic regimes are susceptible to the P-glycoprotein efflux activity. Among these are the vinca alkaloids (vinblastine and vincristine), the taxanes (paclitaxel and docetaxel), the anthracyclines (doxorubicin and daunorubicin), the topoisomerase inhibitors (topotecan and etoposide), and the tyrosine kinase inhibitors (dasatinib and gefitinib). Sunshine Biopharma’s P-glycoprotein evading small molecule, Adva-27a, represents an effective alternative to all of these drugs. 

In addition, it has been recognized that most cancers consist of a heterogeneous population of drug-sensitive and drug-resistant cells. During the course of current chemotherapy regiments, drug-sensitive cells are selectively destroyed and resistant cells become the dominant cancer cell population, leading to recurrence and metastasis. Unlike existing chemotherapy drugs, Adva-27a is able to destroy both populations of cancer cells resulting in more complete eradication of the cancer being treated. 

“The implications of this development are vast in the context of cancer therapy as a whole,” said Dr. Steve Slilaty, CEO of Sunshine Biopharma. “We are excited to soon have a new drug available for cancer sufferers around the world,” he added. 

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SBFM was up well over 100% on Tuesday after the Company announced it has elucidated the mechanism of action of Adva-27a, the Company’s flagship anticancer drug candidate. Adva-27a has been found to have two activities: (i) evasion of P-glycoprotein, and (ii) inhibition of Topoisomerase II. P-glycoprotein is the most often encountered transmembrane efflux protein responsible for multidrug resistance in over 50% of all cancer types. By escaping the efflux pump of P-glycoprotein, Adva-27a is able to accumulate inside cancer cells and destroy them by inhibiting Topoisomerase II, a DNA unwinding enzyme preferentially used by cancer cells to multiply. SBFM took off northbound up the charts earlier this year as the Company’s covid treatment began to gain traciton. In March the Company reported a $2 million investment from RB Capital Partners Inc to further the Company’s covid treatment. Sunshine Biopharma’s COVID-19 treatment is an inhibitor of PLpro, a protease present only in the SARS Coronaviruses (Betacoronaviruses) and is an important antiviral target as it is involved in shutting down the host innate immune system thereby causing significantly greater morbidity. The Company is led by CEO Dr. Slilaty is an accomplished scientist and a highly skilled business executive. He received his Bachelor of Science degree in Genetics and Biochemistry from Cornell University and his Ph.D. in Molecular Biology & Biochemistry from the University of Arizona. Dr. Slilaty is a leader in the bioscience industry and is referenced in editorials, reviews and textbooks. His extensive contributions to science included the discovery of a new class of enzymes (IUBMB Enzyme: EC 3.4.21.88) and the development of key technology for the Human Genome Project (TrueBlue Cloning System). With a passion for medicine, he founded three biotech companies and took one public. The company he took public, Genomics One Corporation reached $1 billion market cap. Microcapdaily was reporting on SBFM when the stock was trading less then $0.01.  We will be updating on SBFM when more details emerge so make sure you are subscribed to Microcapdaily so you know what’s going on with SBFM.

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Disclosure: we hold no position in SBFM either long or short and we have not been compensated for this article.

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