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Tuesday, November 29, 2022

Running With Endonovo Therapeutics Inc (OTCMKTS:ENDV)

Endonovo Therapeutics Inc (OTCMKTS:ENDV) has seen a recent explosive surge in volume and price of its $0.052 lows. The move up comes on the heels of ENDV announcement that they are developing a next-generation, off-the-shelf treatment for Graft-Versus-Host Disease (GVHD) using Cytotronics(TM) expanded and ex vivo enhanced stem cells from the human umbilical cord.

ENDV was incorporated under the laws of Delaware in 2006 as Hanover Portfolio Acquisitions Inc. before they changed their name to Endonovo Therapeutics in May 2014.

Endonovo Therapeutics Inc (OTCMKTS:ENDV) is an innovative biotechnology company developing bioelectronic devices and therapies for regenerative medicine. Endonovo’s Immunotronics(TM) platform is a non-invasive, non-implantable bioelectronic device for treating/preventing vital organ failure through the reduction of inflammation, cell death and the promotion of regeneration.

Endonovo’s Cytotronics(TM) platform provides for a method of expanding and enhancing the biological and therapeutic properties of cells for the development of next-generation cell therapies. The Company’s initial concentration is on the treatment of acute and chronic inflammatory conditions of the liver using its proprietary Immunotronics(TM) platform and the treatment of Graft-Versus-Host Disease using its ex vivo expanded and enhanced stem cells.

Earlier this year ENDV announced the development of a large-scale method for the expansion of umbilical cord blood. ENDV says their technology could allow for a 10x increase in adult stem cell transplants and potentially increase the safety of these treatments by allowing for the expansion of sub-optimal cord blood products that are better matched to patients.

Endonovo’s technology consists of the co-culturing of cord blood mononuclear cells with a portion of the umbilical cord in a three-dimensional rotating wall vessel (RWV) bioreactor, allowing for the expansion of hematopoietic stem cells. The expanded cord blood products would meet the minimal cell requirements for the use of cord blood in adults and potentially result in enhanced engraftment and less toxicities, such as graft versus host disease (GVHD) that occur in lower level HLA matched cord blood units.

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In October ENDV announced two bioelectronic-based platforms for regenerative medicine: Immunotronics(TM), a non-invasive and non-implantable immuno-regulatory device designed to treat inflammatory conditions in vital organs, including acute organ failure; and Cytotronics(TM), a proprietary bioelectronic-based method of expanding and manipulating cells for the creation of cell therapies and tissue engineering.

Endonovo is concentrating its efforts on inflammatory conditions in vital organs and previously announced it’s in the pre-clinical phase of assessing its proprietary Immunotronic technology in the treatment of chronic and acute inflammatory conditions in the liver, including fulminant liver failure.

On November 3 ENDV announced it is developing a next-generation, off-the-shelf treatment for Graft-Versus-Host Disease (GVHD) using Cytotronics(TM) expanded and ex vivo enhanced stem cells from the human umbilical cord.

Endonovo Chief Scientist, Dr. Donnie Rudd said “We have taken our method of expanding a population of immune privileged stem cells from the human umbilical cord and combined it with our Cytotronics platform to create large quantities of optimized immuno-regulatory stem cells that can be used as an allogeneic, off-the-shelf therapy for the treatment of Graft-Versus-Host Disease. Our Cytotronics platform is particularly suited to address many of the issues that have plagued stem cell therapies that have recently failed, such as their loss of potency and self-renewal when expanded ex vivo, their poor engraftment and their limited ability to survive when transplanted,” says Dr. Rudd.

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Currently trading at a $11 million market valuation ENDV has minimal assets or revenues and fast rising debt that could lead to dilution. But ENDV is an exciting story in small caps; the Company is developing bioelectronics-based products and therapies for regenerative medicine. Stem cells have always been an explosive sector and ENDV is always one licensing, royalty deal or JV away from a parabolic move. The stock has shown us already is has runner in its blood. We will be updating on ENDV when more details emerge so make sure you are subscribed to Microcapdaily so you know what’s going on with ENDV.

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Disclosure: we hold no position in ENDV either long or short and we have not been compensated for this article.

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